{"id":8473,"date":"2018-03-15T09:00:22","date_gmt":"2018-03-15T08:00:22","guid":{"rendered":"https:\/\/blog.wika.com\/en\/?p=8473"},"modified":"2022-07-18T13:27:57","modified_gmt":"2022-07-18T11:27:57","slug":"pressure-gauges-for-pharmaceutical-processes-flush-mounted-dry-measurement","status":"publish","type":"post","link":"https:\/\/blog.wika.com\/en\/knowhow\/pressure-gauges-for-pharmaceutical-processes-flush-mounted-dry-measurement\/","title":{"rendered":"Pressure gauges for pharmaceutical processes: Flush-mounted \u201cdry measurement\u201d"},"content":{"rendered":"<p><strong>Are pressure gauges suitable for pharmaceutical processes? Yes, if they are available in a version with flush diaphragm element. There are two advantages for a mechanical pressure measurement with this type of instrument: Diaphragm pressure gauges measure \u201cdry\u201d and thus reduce the risk of contamination. In addition, they offer a reliable measurement, even in critical situations, due to their extremely robust diaphragm element and the high overload safety.<\/strong><\/p>\n<p>In numerous pharmaceutical processes, diaphragm seal systems are used to control the process pressure, also in combination with a pressure gauge. A diaphragm seal separates the measuring instrument from the process and thus protects it against influences. Its sensitive diaphragm for the transmission of pressure through liquid is relatively thin, due to the accuracy of measurement. Compared to the diaphragm as the pressure sensing element of a diaphragm pressure gauge, it is therefore more susceptible, both to unpredictable process conditions (pressure peaks, overload) and to mechanical influences. If the diaphragm is damaged, system fill fluid can enter the process.<\/p>\n\n      <div class=\"wp-caption alignright\" style=\"max-width:396px;\"><img decoding=\"async\" src=\"https:\/\/blog.wika.com\/en\/files\/2018\/03\/pg43sa-388x291.jpg\" \/><p class=\"wp-caption-text\">The mechanism of a PG43SA pressure gauge with flush diaphragm element<\/p><\/div>\n    \n<h2>No contamination<\/h2>\n<p>Pressure gauges with a flush diaphragm element eliminate such contamination since they operate without liquid. Their robust diaphragm element transmits the pressure, via a link, directly to the movement. It is two to five times as thick as a conventional diaphragm seal diaphragm. The diaphragm element is therefore effectively protected against unexpected physical effects. In addition, it can absorb a high overload \u2012 with WIKA instruments this is up to five times the nominal pressure.<\/p>\n<p>Furthermore, pressure gauges for pharmaceutical processes must meet the stringent requirements for sanitary applications in every respect. This has been implemented by WIKA in its PG43SA series. For their instruments, a diaphragm element of only 35 mm in diameter was developed. Due to its special wave contour and the thickness of its material, the diaphragm has a measuring quality comparable to the diaphragm element of a typical process instrument &#8211; though this would be more than twice the size for a comparable pressure range.<\/p>\n<h2>Easily cleanable<\/h2>\n<p>All instruments of the PG43SA series comply with the guidelines of hygienic design, the 3-A Sanitary Standard and are certified to EHEDG. They are suitable for CIP\/SIP processes and are optionally completely autoclavable.<\/p>\n<p>Two of the models (PG43SA-S and PG43SA-D) are pressure gauges with a radial process connection. For the model PG43SA-C, however, the process connection is integrated into the case. This patent-pending design enables space-saving and therefore flexible installation.<\/p>\n<h2>Integrated safety system<\/h2>\n<p>The model PG43SA-D has been tuned to suit particularly critical processes. The pressure gauge has a patent-pending integrated safety system. It includes a second protective barrier and diaphragm element monitoring. Should an unexpected diaphragm rupture occur, the process and measuring instrument remain securely separated. The medium cannot escape into the environment and likewise, nothing contaminating can find its way into the process. Any instance of damage becomes known immediately: The diaphragm element monitoring reports it directly via a red indicator on the dial.<\/p>\n\n      <div class=\"wp-caption aligncenter\" style=\"max-width:846px;\"><img decoding=\"async\" src=\"https:\/\/blog.wika.com\/en\/files\/2018\/03\/pg43sa_ger\u00e4tereihe_2-838x280.jpg\" \/><p class=\"wp-caption-text\">Designed as pressure gauges for pharmaceutical processes (f. l. t. r.): Model PG43SA-S (standard), model PG43SA-C (process connection in case) and model PG43SA-D (with additional safety system).<\/p><\/div>\n    \n<p><strong><br \/>\nNote<\/strong><br \/>\nFor detailed information about the three diaphragm pressure gauges <a href=\"https:\/\/www.wika.com\/en-en\/pg43sa_s.WIKA\" rel=\"external\" target=\"_blank\">PG43SA-S<\/a>, <a href=\"https:\/\/www.wika.com\/en-en\/pg43sa_d.WIKA\" rel=\"external\" target=\"_blank\">PG43SA-D<\/a> and <a href=\"https:\/\/www.wika.com\/en-en\/pg43sa_c.WIKA\" rel=\"external\" target=\"_blank\">PG43SA-C<\/a>, please visit the WIKA website. A concise overview is provided by the <a href=\"https:\/\/www.wika.com\/media\/Brochures-and-flyers\/Products_Services\/fl_pg43sa_en_co.pdf\" rel=\"external\" target=\"_blank\">flyer<\/a> for this instrument family.<\/p>\n<p>For further information please watch the following video about the diaphragm pressure gauges of the PG43SA series:<\/p>\n<div data-fullscreen=\"disabled\" data-mode=\"normal\" data-oembed=\"1\" data-provider=\"youtube\" data-reset-after-played id=\"arve-youtube-dha4xrdjp88\" style=\"max-width:900px;\" class=\"arve\">\n<div class=\"arve-inner\">\n<div style=\"aspect-ratio:500\/281\" class=\"arve-embed arve-embed--has-aspect-ratio\">\n<div class=\"arve-ar\" style=\"padding-top:56.200000%\"><\/div>\n<p>\t\t\t<iframe allow=\"accelerometer &apos;none&apos;;autoplay &apos;none&apos;;bluetooth &apos;none&apos;;browsing-topics &apos;none&apos;;camera &apos;none&apos;;clipboard-read &apos;none&apos;;clipboard-write;display-capture &apos;none&apos;;encrypted-media &apos;none&apos;;gamepad &apos;none&apos;;geolocation &apos;none&apos;;gyroscope &apos;none&apos;;hid &apos;none&apos;;identity-credentials-get &apos;none&apos;;idle-detection &apos;none&apos;;keyboard-map &apos;none&apos;;local-fonts;magnetometer &apos;none&apos;;microphone &apos;none&apos;;midi &apos;none&apos;;otp-credentials &apos;none&apos;;payment &apos;none&apos;;picture-in-picture;publickey-credentials-create &apos;none&apos;;publickey-credentials-get &apos;none&apos;;screen-wake-lock &apos;none&apos;;serial &apos;none&apos;;summarizer &apos;none&apos;;sync-xhr;usb &apos;none&apos;;web-share;window-management &apos;none&apos;;xr-spatial-tracking &apos;none&apos;;\" allowfullscreen=\"\" class=\"arve-iframe fitvidsignore\" credentialless data-arve=\"arve-youtube-dha4xrdjp88\" data-lenis-prevent=\"\" data-src-no-ap=\"https:\/\/www.youtube-nocookie.com\/embed\/dhA4XRDjP88?feature=oembed&amp;iv_load_policy=3&amp;modestbranding=1&amp;rel=0&amp;autohide=1&amp;playsinline=0&amp;autoplay=0&amp;enablejsapi=1\" frameborder=\"0\" height=\"505.8\" loading=\"lazy\" name=\"\" referrerpolicy=\"strict-origin-when-cross-origin\" sandbox=\"allow-scripts allow-same-origin allow-presentation allow-popups allow-popups-to-escape-sandbox\" scrolling=\"no\" src=\"https:\/\/www.youtube-nocookie.com\/embed\/dhA4XRDjP88?feature=oembed&#038;iv_load_policy=3&#038;modestbranding=1&#038;rel=0&#038;autohide=1&#038;playsinline=0&#038;autoplay=0&#038;enablejsapi=1\" title=\"Safe pressure measurement in sanitary applications | Diaphragm pressure gauges in hygienic design\" width=\"900\"><\/iframe><\/p><\/div>\n<\/p><\/div>\n<p>\t<script type=\"application\/ld+json\">{\"@context\":\"http:\\\/\\\/schema.org\\\/\",\"@id\":\"https:\\\/\\\/blog.wika.com\\\/en\\\/knowhow\\\/pressure-gauges-for-pharmaceutical-processes-flush-mounted-dry-measurement\\\/#arve-youtube-dha4xrdjp88\",\"type\":\"VideoObject\",\"embedURL\":\"https:\\\/\\\/www.youtube-nocookie.com\\\/embed\\\/dhA4XRDjP88?feature=oembed&iv_load_policy=3&modestbranding=1&rel=0&autohide=1&playsinline=0&autoplay=0&enablejsapi=1\",\"name\":\"Safe pressure measurement in sanitary applications | Diaphragm pressure gauges in hygienic design\",\"thumbnailUrl\":\"https:\\\/\\\/i.ytimg.com\\\/vi\\\/dhA4XRDjP88\\\/hqdefault.jpg\",\"uploadDate\":\"2019-04-11T13:19:09Z\",\"author\":\"WIKA Group\",\"description\":\"Diaphragm pressure gauge and their role in the production of food and pharmaceuticals. The highest priority in those areas is safety. In sanitary applications, such as, for example, in the production of vaccines or baby food, the purity, quality, and stability of the product must be ensured.\\nIn pipelines, fermenters, bioreactors, or vessels, the pressure needs to be indicated via easy-to-read pressure gauges. Pressures and vacuums must be monitored constantly during cleaning (CIP\\\/SIP), sterilisation and testing.\\nThe process reliability can be guaranteed through measuring instruments in hygienic design. In the following, we will introduce you to the most important instruments, the process risks, and innovative solutions.\\n\\n#FoodSafety #Pharma #WIKAgroup #Pharmaceuticals #Sanitary #SterileProcessing #FoodIndustry\\n\\n\\u25ac Chapters of the video \\u25ac\\u25ac\\u25ac\\u25ac\\u25ac\\u25ac\\u25ac\\u25ac\\u25ac\\u25ac\\n00:00 - Introduction\\n00:36 - Diaphragm seal systems\\n01:37 - Diaphragm pressure gauges\\n02:08 - Special diaphragm pressure gauges by WIKA\\n2:38 - PG43SA-S diaphragm pressure gauge for mobile tanks\\n2:55 - PG43SA-C diaphragm pressure gauge for limited spaces\\n3:11 - PG43SA-D diaphragm pressure gauge for stringent safety requirements\\n\\nDiaphragm seal systems have long proven themselves as a standard. The diaphragm of the diaphragm seal transmits the pressure to the sensor element of the pressure gauge (video:  Mechanical and electronic pressure measuring instruments can be combined with diaphragm seals to adapt the instrument for high temperatures, aggressive media or for easy cleanability.\\nThrough carelessness such as rough handling, but also as a result of pressure spikes and overload, the sensitive diaphragm of the diaphragm seal can be damaged. If the diaphragm rupture is not detected in time or even if the transmission fluid flows into the process, this involves process risks. The consequences could cause great economic damage and even be fatal: contamination of medicines, destruction of entire batches or suspension of production.\\nWith special WIKA pressure measuring instruments, a diaphragm rupture can be detected immediately. Diaphragm seal systems with built-in diaphragm monitoring or diaphragm pressure gauges can reliably monitor such processes.\\nDiaphragm pressure gauges: Here, the pressure is transmitted mechanically to the movement \\u2212 this is done without any transmission fluid and thereby increases the process reliability (video:  Because the diaphragm element is very robust, it is resilient to extreme process conditions as well as rough handling. Thus, diaphragm pressure gauges eliminate a large number of process risks in sanitary applications and increase the plant availability and the service life of the measuring instrument.\\n\\nThe solution: PG43SA series diaphragm pressure gauges are designed to meet the highest demands of the food and pharmaceutical industries. These pressure gauges fulfil the strict requirements of hygienic design and this is confirmed through 3-A and EHEDG certificates. Bioreactors, fermenters or buffer tanks can be autoclaved directly along with the measuring instruments. Dismounting them is not necessary, saving valuable time.\\n\\nPG43SA-S diaphragm pressure gauge ( The pressure in mobile and high vessels, fermenters or bioreactors can be read off using the PG43SA-S diaphragm pressure gauge. It features a large display. Due to the radial connection, this model is also particularly well suited for connection to horizontal pipelines.\\n\\nPG43SA-C diaphragm pressure gauge ( The compact PG43SA-C diaphragm pressure gauge with its patented design is ideal for mounting on vertical pipelines or small mobile vessels. The process connection is located at the rear of the case and enables space-saving installation. \\n\\nPG43SA-D diaphragm pressure gauge ( The high-end model PG43SA-D version meets the highest safety requirements and can completely eliminate the risk of undiscovered diaphragm element ruptures. This is ensured through the integrated diaphragm element monitoring. Via an additional indication on the dial, the integrity of the diaphragm element can be checked with just one glance, not only before installation, but also during operation. A second barrier enables double security and guarantees that media cannot enter into the process or the environment. The process is therefore hermetically sealed in the event of a diaphragm element rupture. If the monitoring function is required for pressure measuring instruments with an electrical output signal, the diaphragm monitoring system with diaphragm seal ( is available for this purpose.\\n\\nBlog posts on the subject: \\n\\n\\u25ac Follow us \\u25ac\\u25ac\\u25ac\\u25ac\\u25ac\\u25ac\\u25ac\\u25ac\\u25ac\\u25ac\\u25ac\\u25ac\\n\\ud83d\\udcfa YouTube: \\n\\u2705 LinkedIn:\"}<\/script><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Are pressure gauges suitable for pharmaceutical processes? Yes, if they are available in a version with flush diaphragm element. There are two advantages for a mechanical pressure measurement with this type of instrument: Diaphragm pressure gauges measure \u201cdry\u201d and thus reduce the risk of contamination. In addition, they offer a reliable measurement, even in critical [&hellip;]<\/p>\n","protected":false},"author":115,"featured_media":8478,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5],"tags":[714,75],"class_list":["post-8473","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-knowhow","tag-pharmaceuticals-and-biotechnology","tag-pressure-gauge"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Pressure gauges for pharmacy: \u201cdry measurement\u201d - WIKA blog<\/title>\n<meta name=\"description\" content=\"Pressure gauges for pharmaceutical processes: Diaphragm pressure gauges measure \u201cdry\u201d and thus reduce the risk of contamination.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.wika.com\/en\/knowhow\/pressure-gauges-for-pharmaceutical-processes-flush-mounted-dry-measurement\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pressure gauges for pharmacy: \u201cdry measurement\u201d - WIKA blog\" \/>\n<meta property=\"og:description\" content=\"Pressure gauges for pharmaceutical processes: Diaphragm pressure gauges measure \u201cdry\u201d and thus reduce the risk of contamination.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blog.wika.com\/en\/knowhow\/pressure-gauges-for-pharmaceutical-processes-flush-mounted-dry-measurement\/\" \/>\n<meta property=\"og:site_name\" content=\"WIKA blog\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blog.wika.com\/en\/files\/2018\/03\/beitragsbild_manometer_pharma.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"838\" \/>\n\t<meta property=\"og:image:height\" content=\"471\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Silvia Weber\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Silvia Weber\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/blog.wika.com\/en\/knowhow\/pressure-gauges-for-pharmaceutical-processes-flush-mounted-dry-measurement\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/blog.wika.com\/en\/knowhow\/pressure-gauges-for-pharmaceutical-processes-flush-mounted-dry-measurement\/\"},\"author\":{\"name\":\"Silvia Weber\",\"@id\":\"https:\/\/blog.wika.com\/en\/#\/schema\/person\/15d6c929ebbeb94dbedd482d363c942d\"},\"headline\":\"Pressure gauges for pharmaceutical processes: Flush-mounted \u201cdry measurement\u201d\",\"datePublished\":\"2018-03-15T08:00:22+00:00\",\"dateModified\":\"2022-07-18T11:27:57+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/blog.wika.com\/en\/knowhow\/pressure-gauges-for-pharmaceutical-processes-flush-mounted-dry-measurement\/\"},\"wordCount\":612,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/blog.wika.com\/en\/knowhow\/pressure-gauges-for-pharmaceutical-processes-flush-mounted-dry-measurement\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/blog.wika.com\/en\/files\/2018\/03\/beitragsbild_manometer_pharma.jpg\",\"keywords\":[\"Pharmaceuticals &amp; 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